Gamma scintigraphy is a non- invasive method for imaging the behavior of dosage forms in vivo in animals and humans. Gamma scintigraphy requires the presence of γ- emitting radioactive isotope in the dosage form that can be detected in vivo by an external gamma camera. Gamma emitting radionuclide is tagged with the active constituent or the excipients of the formulation. The radioactive dosage form is administered via the intended route of administration and the subject (human/animal) is scanned under a gamma camera. Radionuclide tagged drugs/formulations/devices can provide vital information regarding the extent, rate, site, and mode of drug release and morphology of the drug delivery system during release in humans under ethical norms. Pharmacokinetics and Pharmacodynamics of new drug molecules studied by this technique give qualitative as well as quantitative data.
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